Bulk pharmaceutical ingredients are industrially synthesized compounds used as active pharmaceutical ingredients (API). Intermediates are organic chemical compounds used as intermediate materials in pharmaceuticals, paints, and dyes. In addition to the business of API and intermediates including contract manufacturing, energies are also being channeled into development of bulk pharmaceuticals for generic drugs, which are being promoted by the Japanese government, and raw materials for supplements.
In the production of pharmaceutical ingredients, Tokuyama follows Good Manufacturing Practice (GMP) guidelines to manufacture products of the finest quality in accordance with the Pharmaceuticals and Medical Devices Law of Japan. GMP comprises structural facility standards for factories, as well as production management and quality control standards. At our Kashima Factory, we produce high-quality products based on facilities and management practices that are compliant with GMP standards.
Tokuyama engages in the process development of active ingredients and production of bulk pharmaceutical ingredients and intermediates for medicines for improving digestive functions, allergy remedies, eye drops, antipsychotics and drugs for lifestyle diseases such as diabetes and hypertension, which are now priority fields for medicine. Tokuyama can adjust production schedules according to customers' demand because it owns a wide array of reactor vessels ranging from 10 liters to 5,000 liters.
Through its operations in optical materials and electronic materials, Tokuyama has developed technologies for organic synthesis, crystallization and analysis that can be applied in a broad range of fields. In addition, Tokuyama can efficiently produce bulk pharmaceutical ingredients of exceptionally high purity by means of exclusive facilities such as columns filled with resins and active carbon, that enables to apply purification operations tailored to the property of each chemical compound to production processes.